Cannabis medications were traditionally famous for treating nausea and the traditional knowledge is now being used to develop modern anti-nausea CBD medicines. CBD is one among the cannabinoids in hemp, a cannabis plant cultivated from the ancient times as a food and industrial crop.
Before we discuss how CBD works to treat nausea, it is important to know the details of the condition, diseases that have associated nausea symptoms, etc.
What Is Nausea?
Gastrointestinal discomfort that is followed by the urge to vomit is generally referred to as nausea. In normal cases, nausea is part of the defensive mechanism of the body and does not last that long. However, nausea that surfaces in the absence of any potential trigger and lasts long may be indicative of some serious underlying conditions.
Excessive salivation, pallor, cold sweat, duodenal contraction, etc are associated with the experience of nausea. Although vomiting reflux commonly follows nausea, it may sometimes occur alone.
What Are The Possible Causes Of Nausea?
Nausea could be associated with several health conditions including:
- Bacterial infections
- Head injury
- Emotional disorders
It may also occur as a result of treatments like chemotherapy, poisoning by heavy metals, etc.
What Happens In Our Body When We Are Nauseated?
Nausea is termed as emesis. The mechanism of emesis is explained below:
The central nervous system handles the emetic signals and relays then to different parts of the body related to the emetic response mechanism. Afferent inputs are initially sent to the central nervous system. Upon receiving the emetic signals, they are centrally processed after which they form efferent signals. The chemical efferent pathway relays the signals that connect to the coordinated gastrointestinal, respiratory, and abdominal actions of vomiting.
How Does CBD Manage Nausea Symptoms?
Anti-nausea effects of CBD are attributed to the interaction of serotonin releasing receptors. Nausea response is triggered by the binding of the neurotransmitter serotonin to the serotonin receptors. By inhibiting the binding action, CBD produces the desired anti-nausea effects.
Research has suggested that CBD reduces the release of serotonin from the forebrain, thereby suppressing nausea response caused by nausea. The neurotransmitter anandamide is found to have anti-nausea properties but the presence of fatty acid amide hydrolase (FAAH) leads to faster degradation of anandamide. Studies have reported that CBD has the ability to reduce the levels of FAAH in the body, thereby making positive contributions to the anandamide levels in the body.
When considering the effect on serotonin receptors, the acidic form of CBD, CBDA is found to be more effective than CBD is. CBDA exists in the growing CBD-rich plant before the plant matter is dried and heated. On heating, CBDA decarboxylates to CBD.
Using CBD To Treat Nausea Associated With Chemotherapy
The Nocebo effect is the state of mind that is sometimes part of chemotherapy treatment. It is the opposite of the placebo effect. When you are given a fancy drug and told that it will offer complete relief from the ailment you are suffering from, it makes a positive impact on your mind and makes positive contributions to the medication course.
Nocebo effect works the opposite way to that of the placebo effect. If you are given a medical drug and told that it will have severe side effects, you will then actually begin to show the negative symptoms. when you fear the possible side effects of chemotherapy, there are chances that the side effects may actually surface.
Comparing The Effectiveness Of CBD And THC In Nausea Treatment
THC, the cannabis compound is similar to CBD in treating nausea. Whether it is natural or synthetic, THC prevents the serotonin from binding to receptors and interacts with receptors in the reflex pathways as well as in the brainstem.
Research has given evidence for the effectiveness of both CBD and THC in treating nausea. As CBD doesn’t cause high unlike THC, people mostly prefer CBD for anti-nausea treatment. Both CBD and THC reduce nausea by blocking serotonin receptors and both are equally effective in preventing gaping.
Guide To Dosage Of CBD Oil For Nausea
There exist no official dosage recommendations for CBD oil to treat nausea. The dosage that works best for one person may not be the ideal dosage for the other. It is generally recommended that you start with low dosages and increase it gradually until you find out what dosage is best for you. The right CBD dosage for you depends on your body weight, tolerance level to CBD, the severity of the medical condition you are treating, and potency of the CBD product.
In some cases, nausea may be induced by anxiety disorder too. The anxiolytic properties of cannabidiol prove effective in treating anxiety-induced nausea.